Rheostat positions: A new classification of protein positions relevant to pharmacogenomics
نویسندگان
چکیده
منابع مشابه
Computational predictors fail to identify amino acid substitution effects at rheostat positions
Many computational approaches exist for predicting the effects of amino acid substitutions. Here, we considered whether the protein sequence position class - rheostat or toggle - affects these predictions. The classes are defined as follows: experimentally evaluated effects of amino acid substitutions at toggle positions are binary, while rheostat positions show progressive changes. For substit...
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Evolution in its course has found a variety of solutions to the same optimisation problem. The advent of high-throughput genomic sequencing has made available extensive data from which, in principle, one can infer the underlying structure on which biological functions rely. In this paper, we present a new method aimed at the extraction of sites encoding structural and functional properties from...
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متن کاملPositions available
CELL publishes advertisements for positions available and for announcements of meetings, symposia, and courses. The 1995 rates are $425 for a quarter page, $695 for a half page, and $1100 for a full page. We will accept either camera-ready material by mail, or copy to be typeset by mail or fax. If you choose to have your ad typeset by CELL, the size of the ad will be determined by the number of...
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ژورنال
عنوان ژورنال: Medicinal Chemistry Research
سال: 2020
ISSN: 1054-2523,1554-8120
DOI: 10.1007/s00044-020-02582-9